So much for caloric abandonment weekends.
New research confirms that only two days of eating a high -fat diet can compromise critical immune cells in the intestine and weaken the intestinal obstruction, suggesting that the impact of our daily dietary choices is more immediate than previously believed.
Published this month in the journal Immunity, the research followed by rats fed a regular diet, a high fat diet and specialized diet enriched with saturated and unsaturated fats.
The high fat diet led to the rapid suppression of specialized immune cells called ILC3s, which produce a protective substance called Interleukin-22 (IL-22). This pressure is catastrophic for the digestive system.
Inside the intestines, IL-22 usually protects the intestinal barrier by generating protective elements that prevent bacteria, toxins, unsaturated food particles and inflammatory pathogens by violation of blood flow.
When a high-fat diet limits the production of IL-22, it becomes more permeable, an inevitable, inevitable condition, as “running intestine”.
While not an official diagnosis, the running intestine is known to cause bloating, constipation, indigestion, acid reflux and potentially intestinal pain.
What’s what is worse, when toxins flow beyond the intestines, they cause widespread inflammation, leading to issues such as skin problems, brain fog, anxiety, depression, cardiovascular stress and even fertility challenges.
“The more saturated fats we eat, the more inflammation that is built,” said study author Cyril Seilet from the Institute of Medical Research Walter and Eliza Hall in Australia. “This construction of inflammation is initially silent, remaining hidden in our bodies until years later, where it can be presented as chronic inflammation.”
Seillet and his team found that different fats have extremely different effects on overall intestinal health.
They found that unsaturated fatty acids, found in olive oil and avocado, helped support the normal production of IL-22 and the function of intestinal barriers.
In contrast, saturated fatty acids, present in palm oil, butter and fatty animal meat, give a one-two handful, seriously inhibiting the function of immune cells and increasing intestinal inflammation.
After only two days in high-fat diets, researchers observed that certain subtypes of ILC3 immune cells already exhibited reduced production of IL-22. One week in the high -fat diet, all ILC3 subtypes were endangered.
Further, within a week in the high -fat diet, the intestinal microbiomy was rapidly displaced, exhibiting a decrease in beneficial bacteria that produce short -chain fatty acids and a spread of harmful bacteria.
Using specialized equipment, the research team stood out that one week in a high -fat diet was associated with the intestines of “flow” mice, a permeability that allowed them to pass more dangerous substances.
There is a row of silver (intestine) that can be found in this last set of research-consequences of intestinal compromise of a high fat diet are not permanent.
The research team revealed that after resuming a regular diet, the intestinal function improved after only two days and returned to normal after seven days. This rapid correction suggests that dietary interventions can rapidly restore bowel health.
Moreover, researchers found that saturated and unsaturated fatty acids are processed in quite different ways.
Saturated fats are processed through a path called fatty acid oxidation, which damages immune function, while unsaturated fats such as oleic acid form lipid protective points in cells, helping to maintain proper immune responses.
To demonstrate how the processing of these fats affects the intestinal inflammation, the research team caused colitis in mice. Mice fed saturated fats showed greater tissue damage than those that ate unsaturated fats or respected a regular diet.
The results were similar when the team exposed the human isolated immune cells to various fatty acids. Basically, unsaturated fats support immune function while saturated fats suppress IL-22 output.
Researchers believe that these rapid and profound changes in intestinal health can explain why people experience digestive discomfort when leaving their regular diets during the holidays or on vacation.
In contrast, these results serve to explain why diets rich in olive oil and unsaturated fats, such as the glorified Mediterranean diet, are associated with lower levels of inflammation and improving intestinal health.
How important is intestinal health? Research reports that Parkinson’s disease can begin in the gut.
A 2022 study by New York University, even found a possible link between a person’s intestinal health and personality.
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