A true pain of pain!
University researchers have designed a powerful facilitator of promising pain – seemingly without harmful side effects and high levels of opioids.
While opioids interact with numerous cellular pathways, the experimental drug is more selective. The SBI-810 targets a receptor in the brain and spinal cord, activating a single signal for relieving pain as it directs the cleansing of other signals that can cause problematic consequences.
“What makes this complex exciting complex is that it is both analgesic and non-opioid,” said the high author of the study Rr-Rong Ji, an anesthesiology and neurobiology researcher who directs the Duke Anesthesiology Center for translation pain medicine.
“[The receptor] It is a promising objective for the treatment of acute and chronic pain, ”Ji added.
Chronic pain is a constant problem in the USA nearly a quarter of adults, about 62 million, experienced it in 2023.
Chronic pain has helped promote the opioid crisis. About 8.6 million Americans 12 years and older reported the abuse of prescription opioids in 2023.
And almost 70% of the deaths of drug overdosation 107,000-plus in the US are attributed to opioids such as fentanyl.
The good news is that there has been recent progress on this front, with more treatment options and fewer deaths associated with opioids.
Too too early to show if the SBI-810 can help the cause. The drug has not been completely tested in people, but the results in mice have been encouraging.
Opioids like morphine often lead to tolerance with repeated use, requiring higher or more frequent doses to maintain the same level of pain control.
The SBI-810 relieved pain from surgical incisions, bone fractures and nerve damage without a tolerance or constipation construction, another common side effect.
When associated with small doses of opioids, the SBI-810 made them more effective in lower doses.
And it is said to work better than the sedatives of olceridine sedatives and gabapent in certain situations.
The findings were recently published in Cell magazine.
The Ji team has provided some patents for the SBI-810 and hopes to start human rehearsals soon.
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Image Source : nypost.com