Drugs that makes “our happiest brains can also fight tumors: study

This will illuminate your mood.

A new startling study has found that some common medicines used to make people feel better can also be effective in the fight against cancer.

“These medicines have been widely and securely used to treat depression for decades, so their burial for cancer would be much easier than developing a whole new therapy, â € â Dr. Lili Yang, a member of â Eli and Edythe Broad Center for regenerative drugs and study cells in UCLA.

Yang and her team found that selective inhibitors of serotonin recovery, or SSRIS-Medikaments like Prozac and Celexa that millions of Americans get every day and can help T treat tumors with a larger aplomb.

“It turns out that Ssris does not make our brains happier; they also make our t-cells happier-and why they are fighting tumors,” she said.

In laboratory tests using both mouse and human tumor models – including melanoma, breast, prostate, colon and bladder cancers – ssis reduced tumors by over 50%.

The drugs increased the activity of the killing cells, increasing their ability to find and destroy cancer cells.

â € Assris made killer cells happier in the other oppressive tumor environment by increasing their access to serotonin signals, renewing them to fight and kill cancer cells, “Yang said.

While serotonin is mainly known for regulating mood, it also plays a crucial role in managing sleep, intestinal health, appetite, libido and blood clotting.

Now, it is being given properly due to the fight against this devastating disease.

The research, which was published in the journal Cell, has exciting implications for cancer treatment, as SSRIs are already approved by the FDA, paving the way for clinical rehearsals.

â € œtudies Evaluate the pipeline in bed for new cancer therapies costs an average of $ 1.5 billion, ”she said.

“When you compare this to the estimated cost of $ 300 million to rebuild the FDA -approved medicines, it is clear why this approach has so much potential.

Even better?

When SSRI was paired with existing cancer immunotherapy, the results were even more dramatic.

The treated rats saw the tumors decrease dramatically, and in some cases disappear altogether.

Immune control point blockades are effective in less than 25% of patients, said study co-author James Elsten-Brown, a graduate student at Yang Laboratory.

â € œ If a safe drug, available as a SSRI could make these therapy more effective, would be extremely influential.â €